research

Publications

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InputDSA: Demixing, then comparing recurrent and externally driven dynamics

Huang, A., Ostrow, M., Singh, S. H., Kozachkow, L., Fiete, I., & Rajan, K.*

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Data-derived agents reveal dynamical reservoirs in mouse cortex for adaptive behavior

Zhou S., Badman, R., Arlt, C., Rajan, K.*, & Harvey, C.

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Active electrosensing and communication in MARL-trained weakly electric fish collectives

Singh, S., Johnson-Yu, S., Lu, Z., Walsman, A., Pedraja, F., Turcu, D., Sharma, P., Saphra, N., Sawtell, N., & Rajan, K.

2026
arXiv
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Inferring brain-wide interactions using data-constrained recurrent neural network models

Perich, M.G., Arlt, C., Soares, S., Zhou, S., Beiran, M., Andalman A.S., Benster, T., Young, M.E., Mosher, C.P., Minxha, J., Carter, E., Rutishauser, U., Rudebeck, P.H., Harvey, C.D., Deisseroth, K., & Rajan, K.*

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Stress history modulates corticotropin-releasing factor neurons to establish resilience

Haynes, S. E., Lacagnina, A., Seo, H. S., Li, F., Yang, X., Afzal, M., Morel, C., Menigoz, A., Rajan, K., Clem, R. L., Juarez, B., Mayberg, H. S., Rainnie, D. G., Young, L. J., & Han, M. H.

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Dissecting larval zebrafish hunting using deep reinforcement learning trained RNN agents

Malik, R., Singh, S. H., Johnson-Yu, S., Wu, N., Harpaz, R., Engert, F., Rajan, K.

2025
arXiv
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From memories to maps: Mechanisms of in-context reinforcement learning in transformers

Fang, C., & Rajan, K.

2025
arXiv
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A variational manifold embedding framework for nonlinear dimensionality reduction

Vastola, J., Gershman, S. J., & Rajan, K.

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POCO: Scalable neural forecasting through population conditioning

Duan, Y., Chaudhry, H.T., Ahrens, M.B., Harvey, C.D., Perich, M.G., Deisseroth, K., & Rajan, K.

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Gradient descent as loss landscape navigation: A normative framework for deriving learning rules

Vastola, J., Gershman, S. J., & Rajan, K.

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Military AI needs technically-informed regulation to safeguard AI research and its applications

Simmons-Edler, R., Dong, J., Lushenko, P., Rajan, K., & Badman, R.P.

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Deep RL needs deep behavior analysis: Exploring implicit planning by model-free agents in open-ended environments

Simmons-Edler, R., Badman, R.P., Berg, F.B., Chua, R., Vastola, J.J., Lunger, J., Qian, W., & Rajan, K.

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Measuring and controlling solution degeneracy across task-trained recurrent neural networks

Huang, A., Singh, S. H., & Rajan, K.

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Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance

Insanally, M.N., Albanna, B.F., Toth, J., DePasquale, B., Fadaei, S.S., Gupta, T., Lombardi, O., Kuchibhotla, K., Rajan, K., & Froemke, R.C.

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The time is ripe to reverse engineer an entire nervous system: Simulating behavior from neural interactions

Haspel, G., Baker, B., Beets, I., Boyden, E. S., Brown, J., Church, G., Cohen, N., Colon-Ramos, D., Dyer, E., Fang-Yen, C., Flavell, S., Goodman, M. B., Hart, A. C., Izquierdo, E. J., Kagias, K., Lockery, S., Lu, Y., Marblestone, A., Matelsky, J., Mensh, B., Pereira, T. D., Pfister, H., Rajan, K., Rotstein, H. G., Scholz, M., Shaevitz, J. W., Shlizerman, E., Simeon, Q., Skuhersky, M. A., Tiruvadi, V., Venkatachalam, V., Wei, D., Wester, B., Yang, G. R., Yemini, E., Zimmer, M., & Kording, K. P.

2024
arXiv
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Representations of the intrinsic value of information in mouse orbitofrontal cortex

Bussell, J. J., Badman, R. P., Márton, C. D., Bromberg-Martin, E. S., Abbott, L. F., Rajan, K., & Axel, R.

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Offline ensemble co-reactivation links memories across days

Zaki, Y., Pennington, Z. T., Morales-Rodriguez, D., Bacon, M. E., Ko, B., Francisco, T. R., LaBanca, A. R., Sompolpong, P., Dong, Z., Lamsifer, S., Chen, H. T., Carrillo Segura, S., Christenson Wick, Z., Silva, A. J., Rajan, K., van der Meer, M., Fenton, A., Shuman, T., & Cai, D. J.

2024
Nature
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Reflections on simplicity and complexity in computational neuroscience

Rajan, K., Treves, A. & Gaudenzi, R.

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AI-powered autonomous weapons risk geopolitical instability and threaten AI research

Simmons-Edler, R., Badman, R.P., Longpre, S. & Rajan, K.

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Behavioral fingerprinting of the naked mole-rat uncovers signatures of eusociality and social touch

Schwark, R., Ogundare, S., Weinreb, C., Sheng, P., Foster, W., Toussaint, A., Chang, P., Tsai, Y., Comfere, M., Arnold, A., Guadagnino, A., McCloskey, D., Schaffer, E., Rajan, K., Datta, S., & Abdus-Saboor, I.

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Temporally specific patterns of neural activity in interconnected corticolimbic structures during reward anticipation

Young, M.E., Spencer-Salmon, C., Mosher, C., Tamang, S., Rajan, K., & Rudebeck, P.H.

2023
Neuron
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Network models to enhance the translational impact of cross-species studies

Brynildsen, J.K., Rajan, K., Henderson, M.X., & Bassett, D.S.

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The computational brain

Clem, R.L., Cai, D.J., Rajan, K., Shuman, T., Wu, X., & Wu, Z.

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A ‘programming’ framework for recurrent neural networks

Beiran, M., Spencer-Salmon, C.A., & Rajan, K.

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Amplified cortical neural responses as animals learn to use novel activity patterns

Akitake, B., Douglas, H.M., LaFosse, P.K., Deng, Y., Rajan, K., & Histed, M.H.

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Aversive experience drives offline ensemble reactivation to link memories across days

Zaki, Y., Pennington, Z.T., Morales-Rodriguez, D., Francisco, T.R., La Banca, A.R., Dong, Z., Carrillo Segura, S., Silva, A.J., Shuman, T., Fenton, A., Rajan, K., & Cai, D.J.

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A brain basis of dynamical intelligence for AI and computational neuroscience

Monaco, J.D., Rajan, K., & Hwang, G.M.

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Efficient and robust multi-task learning in the brain with modular latent primitives

Márton, C. D., Gagnon, L., Lajoie, G.^, & Rajan, K.^

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Curriculum learning as a tool to uncover learning principles in the brain

Kepple, D.R., Engelken, R.E., & Rajan, K.*

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Reservoir-based tracking (TRAKR) for one-shot classification of neural time-series patterns

Afzal, M. Q., Márton, C. D., Mayberg, H.M., Rich, E. L., & Rajan, K.

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Minian: An open-source miniscope analysis pipeline

Dong Z., Mau W., Feng Y., Pennington Z.T., Chen L., Zaki Y., Rajan K., Shuman T., Aharoni D., & Cai D.J.

2022
eLife
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Linking task structure and neural network dynamics

Márton, C.D., Zhou, S., & Rajan, K.

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Deep anomaly detection of seizures with paired stereoelectroencephalography and video recordings

Martini, M.L., Valliani, A.A., Sun, C., Costa, A.B., Zhao, S., Panov, F., Ghatan, S., Rajan, K.*, & Oermann E.K.*

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The Learning Salon: Toward a new participatory science

Momennejad, I., Krakauer, J.W., Sun, C., Yezerets, E., Rajan, K., Vogelstein, J.T., & Wyble, B.

2021
Neuron
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Machine learning with feature domains elucidates candidate drivers of hospital readmission following spine surgery in a large single-center patient cohort

Martini, M.L., Neifert, S.N., Oermann, E.K., Gal, J., Rajan, K., Nistal, D.A., & Caridi, J.M.

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Rethinking brain-wide interactions through multi-region ‘network of networks’ models

Perich, M.G, & Rajan, K.

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Neuronal dynamics regulating brain and behavioral state transitions

Andalman, A.S., Burns, V.M., Lovett-Barron, M., Broxton, M. Poole, B. Yang, S.J., Grosenick, L., Lerner, T.N., Chen, R., Benster, T., Mourrain, P., Levoy, M., Rajan, K., & Deisseroth, K.

2019
Cell
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Task-dependent changes in the large-scale dynamics and necessity of cortical regions

Pinto, L., Rajan, K., DePasquale, B., Thiberge, S.Y., Tank, D.W., & Brody, C.D.

2019
Neuron
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Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons

Insanally, M.N., Carcea, I., Field, R.E., Rodgers, C.C., DiPasquale, B., Rajan, K., DeWeese, M.R., Albanna, B.F., & Froemke, R.C.

2019
eLife
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How to study the neural mechanisms of multiple tasks

Yang, G.R., Cole, M.W., & Rajan, K.

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Full-FORCE: A least-squares algorithm for training recurrently connected neural networks

DePasquale, B., Cueva, C., Rajan, K., Escola, G.S., & Abbott, L.F.

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Recurrent network models of sequence generation and memory

Rajan, K., Harvey, C.D., & Tank, D.W.

2016
Neuron
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Maximally informative “stimulus energies” in the analysis of neural responses to natural signals

Rajan, K., & Bialek, W.

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Learning quadratic receptive fields from neural responses to natural stimuli: Information theoretic and likelihood methods

Rajan, K., Marre, O., & Tkacik, G.

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Stimulus-dependent suppression of intrinsic variability in recurrent neural networks

Rajan, K., Abbott, L.F., & Sompolinsky, H.

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Inferring stimulus selectivity from the spatial structure of neural network dynamics

Rajan, K., Abbott, L.F., & Sompolinsky, H.

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Stimulus-dependent suppression of chaos in recurrent neural networks

Rajan, K., Abbott, L.F., & Sompolinsky, H.

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Interactions between intrinsic and stimulus dependent activity in recurrent neural networks

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Nonchaotic responses from randomly connected networks of model neurons

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Temperature compensation of chemical reactions

Rajan, K., & Abbott, L.F.

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Eigenvalue spectra of random matrices for neural networks

Rajan, K., & Abbott, L.F.

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Neural network dynamics

Vogels, T.P., Rajan, K., & Abbott, L.F.

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